Effect of venlafaxine and fluoxetine in depression and improvement on cognitive function
- VernacularTitle:文拉法辛与氟西汀对抑郁症的疗效及对认知功能的改善作用研究
- Author:
Jiqiang HUANG
1
;
Xin GUO
;
Minshi YANG
Author Information
1. 沈阳市精神卫生中心老年科
- Keywords:
Depression;
Venlafaxine;
Fluoxetine;
Cognitive function
- From:
China Modern Doctor
2014;(27):48-50
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effect of venlafaxine and fluoxetine in depression and improvement on cognitive function. Methods Retrospectively analyzed from January 2012 to January 2014 in our hospital for treatment of 32 cas-es of depression with venlafaxine in patients with clinical data, set up for the observation group, selected the same pe-riod of fluoxetine in 32 patients with depression in patients with clinical data, set up as the control group, HAMD score, cognitive function before and after treatment were compared between two groups. Results The total effective rate of ob-servation group after treatment was 93.75%,was significantly higher than the control group (P<0.05). The observation group and the control group of patients with HAMD scores were significantly lower than before treatment, and the HAMD score of observation group was significantly lower than that of the control group (P<0.05). The observation group group after treatment 8 weeks, number of errors, random errors were significantly lower than before treatment, and sig-nificantly less than the control group (P<0.05). Patients in the control group after 8 weeks of treatment, number of perse-verative errors connected rates had no significant difference before treatment (P>0.05). Conclusion Venlafaxine in the treatment of depression and improve the effect on cognitive function, has more advantages than fluoxetine.
