Efficacy of decompensated cirrhosis of lamivudine combined with adefovir dipivoxil
- VernacularTitle:拉米夫定联合阿德福韦酯治疗乙肝肝硬化失代偿期的疗效观察
- Author:
Ling Cheng LIU
1
;
Shuhua LV
Author Information
1. 江西省遂川县人民医院内二科
- Keywords:
Cirrhosis;
Decompensation;
Lamivudine;
Joint;
Adefovir dipivoxil
- From:
China Modern Doctor
2014;(27):45-47
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of lamivudine combined with adefovir decompensatedin in threatment of cirrhosis clinical therapeutic. Methods From January 2012 to January 2014,60 cases of hepatitis B patients with de-compensated cirrhosis were randomly divided into observation group and control group of 30 patients,the observation group were treated with lamivudine 100 mg/d, once a day, and adefovir dipivoxil 10 mg/d treatment , once a day ; the control group plus lamivudine 100 mg/d, once a day. The liver function after treatment of 24 weeks and 48 weeks , HBV-DNA quantification were compared. Results After treatment 48 weeks, ALT and AST of observation group and the control group was significantly lower than before treatment, and ALB increased significantly before treatment,ALT, AST, ALB after treatment of the observation group compared with the control group improved more significantly (P<0.05). HBV-DNA of observation group and the control group of patients was significantly lower than before treatment, and the observation group decreased more significantly than the control group (P<0.05). Conclusion Lamivudine com-bined with adefovir dipivoxil in treatment of decompensated cirrhosis can improve liver function and prognosis, safety, worthy of promotion and application.
