The clinical efficacy of mosapride joint domperidone in treatment of functional dyspepsia
- VernacularTitle:莫沙必利联合多潘立酮治疗功能性消化不良的临床疗效观察
- Author:
Yichu DENG
1
;
Jinghua GU
Author Information
1. 江西省赣县人民医院内三科
- Keywords:
Functional dyspepsia;
Mosapride;
Domperidone;
Relapse
- From:
China Modern Doctor
2014;(27):42-44
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the clinical efficacy of mosapride joint domperidone in treatment of functional dys-pepsia. Methods In our hospital,from June 2011 to January 2014, seleceted 120 FD patients were randomly divided into observation group and control group,60 cases in each group,the control group took domperidone oral,10 mg/time,3 times/d, took half an hour before meals, once every two weeks. Meanwhile study group combined mosapride oral,5 mg/time, 3 times/d, took half an hour before meals, once every two weeks. Closely observed and recorded adverse reactions during treatment. Results The total efficiency of the study group and control group after treatment was 93.3%,78.3%, the difference was statistically significant between two groups (χ2= 6.273,P<0.05). The observation group and the control group of patients with abdominal pain or discomfort, bloating, early satiety, belching and other clinical symptom score after treatment was significantly lower than before treatment,and the observation group was sig-nificantly lower than the control group's the difference was statistically significanct between two groups (P<0.05). After treatment 3 months, two groups patients were followed's the observation group were followed up 52 cases,the control group were followed up for 50 cases, 6 cases of relapse of the observation group, the control group had 14 cases of re-currence,the difference of the recurrence rate was statistically significant between the two groups(χ2=5.137,P<0.05). Conclusion Mosapride joint domperidone in treatment of functional dyspepsia can improve efficacy, improve detailed clinical symptoms,reduce the relapse rate,worthy of promotion and application.
