Clinicopathological correlations of PHLPP expression in non-small cell lung cancer
- VernacularTitle:PHLPP在非小细胞肺癌中的表达及临床意义
- Author:
Youyou XIE
1
;
Dongqing LV
;
Peinong YANG
;
Haihua YANG
Author Information
1. 浙江省台州医院放疗科
- Keywords:
Non-small cell lung cancer(NSCLC);
PHLPP;
Immunohistochemistry(IHC)
- From:
China Modern Doctor
2014;(27):21-23
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of PHLPP in non-small cell lung cancer (NSCLC)and its correla-tions of clinicopathological characteristics. Methods All of 82 tissue specimens with NSCLC were examined with im-munohistochemical staining, and the results of IHC were analyzed with the clinicopathologic characteristics. Results PHLPP mainly expressed on the cell membrane. The rate of PHLPP expression was negative in 63%, poor in 11%, moderate in 10% and strong in 16%, respectively. The expression of PHLPP was significantly correlated with differen-tiation, but not with age, smoking states, pathological type and stage. Conclusion The positive expression rate of PHLPP is 37%in human NSCLC tissue specimens and was correlated with histological differentiation .
