Efficacy of triple therapy and sequential therapy in the eradication of He-licobacter pylori in liver cirrhosis patients with hyperammonia
- VernacularTitle:三联疗法与序贯疗法在肝硬化高氨血症患者中根除幽门螺杆菌的疗效观察
- Author:
Qingjuan HE
1
;
Kuixiang LIU
;
Yanan ZHAO
;
Ying SUN
;
Chengxi WANG
Author Information
1. 青岛市第八人民医院消化内科
- Keywords:
Liver cirrhosis with hyperammonia;
Helicobacter pylori;
Triple therapy;
Sequential therapy
- From:
China Modern Doctor
2014;(26):148-149,152
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the efficacy of triple therapy and sequential therapy in the eradication of helicobacter pylori in liver cirrhosis patients with hyperammonia (Hp). Methods A total of sixty-eight liver cirrhosis patients with hyperammonia and positive Hp infection were randomly divided into triple eradication group and sequential eradication group. Results The eradication rates of Hp in triple therapy group and sequential therapy group were 79.4%(27/34)and 85.3% (29/34)respectively. There was no significant difference between the two groups(χ2=0.41, P>0.05). In the triple therapy group, the blood ammonia concentration of after treatment and one month after withdrawal of drugs de-creased significantly compared with before the treatment (t=4.02, 5.11, P<0.01).In the sequential therapy group, the blood ammonia concentration of after treatment and one month after withdrawal of drugs decreased significantly com-pared with before the treatment (t=4.68, 5.83, P<0.01).The fall of ammonia concentration was not statistical different between the two groups(P>0.05). Conclusion There is no significant difference in Hp eradication between triple therapy and sequential therapy in liver cirrhosis patients with hyperammonia.
