Effects of different dosages of aripiprazole on cognitive function in stabi-lized schizophrenic patients treated with risperidone
- VernacularTitle:利培酮添加不同剂量的阿立哌唑对稳定期精神分裂症患者认知功能的影响
- Author:
Ronghai WEN
1
;
Shi LIU
Author Information
1. 河南省南阳市精神病医院药学部
- Keywords:
Aripiprazole;
Dosage;
Cognitive function;
D2 receptor occupancy;
Balancing status between 5HT1A/D2 partial agonists
- From:
China Modern Doctor
2014;(26):61-63
- CountryChina
- Language:Chinese
-
Abstract:
Objective To probe the effects of dosages of aripiprazole on cognitive function of stabilized schizophrenic outpatients treated with risperidone. Methods A totol of 43 stabilized schizophrenic outpatients received risperidone were randomly divided into two groups. Aripiprazole added to control group (n=22)was taken by (20~30)mg/d and the study group(n=21)did by (5~15) mg/d,respectively, for 12 weeks. Brief Assessment of Cognition in Schizophrenia (BACS,Chinese edition)and Positive and Negative Syndrome Scale (PANSS)were used to evaluate efficacy. Treatment Emergent Symptom Scale (TESS) was used to evaluate adverse effects during this trial. Results The occurring rates of adverse effects for the two groups were not significantly different (P>0.05). Risperidone augmentation with aripiprazole by(5~15)mg/d significantly improved partial cognitive function and negative symptoms for these patients. Add-on treat-ment with aripiprazole by (20~30) mg/d significantly impair working memory(WM) and executive function (EF) (P<0.01), although that significantly improved motor speed (MS) and negative symptoms as the former did. Conclusion Risperidone augmentation with a lower rather than higher dosage of aripiprazole would improve cognitive function most favorably. These findings need further substantial and long-term trials to be established .
