Comparative study of the efficacy of ziprasidone and risperidone in the treatment of schizophrenia
- VernacularTitle:齐拉西酮与利培酮治疗精神分裂症的疗效对比研究
- Author:
Jiqiang HUANG
1
;
Xin GUO
;
Minshi YANG
Author Information
1. 沈阳市精神卫生中心老年科
- Keywords:
Schizophrenia;
Ziprasidone;
Risperidone
- From:
China Modern Doctor
2014;(26):58-60
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the efficacy of zillah risperidone and risperidone in the treatment of schizophrenia. Methods In our hospital from January 2010 to January 2014,selected 60 cases schizophrenic patients hospitalized as observed object,60 cases hospitalized patients with schizophrenia during as the observed object, all patients were ran-domly divided into group A (ziprasidone) and group B (risperidone), each group of 30 patients, before and after treatment efficacy PANSS score changes and two groups of patients after treatment, adverse reactions were compared between two groups. Results After 4,8 weeks, the PANSS total score,PANSS positive symptoms, PANSS negative symptoms of A group and B group were significantly lower than before treatment,the difference was statistically signifi-cant(P<0.05),PANSS scores of A group after treatment 4,8 weeks were significantly lower than in group B,the differ-ence was statistically significant (P<0.05),but after treatment 4,8 weeks,PANSS positive symptoms, PANSS negative symptoms of group A and group B had no significant significance. The total effective rate of A group was 86.7%,was higher than that in group B (83.3%),but the difference was not statistically significant between the two groups (P>0.05). After treatment for 6 weeks,the incidence of adverse reactions of A group was 20%,group B was 40%,the inci-dence of adverse reactions in group A was significantly lower than group B,the difference was statistically significant(P<0.05). Conclusion Ziprasidone and risperidone in the treatment of schizophrenia have better efficacy, but com-pared to risperidone, ziprasidone has advantages,with fewer adverse reactions.
