The therapeutic effect of diabetic sensory neuropathy treated with epal-restat
- VernacularTitle:依帕司他治疗糖尿病感觉神经病变的临床疗效观察
- Author:
Yunzhao TANG
1
;
Changlin NI
;
Weilin WANG
;
Jianming JIN
;
Aili YIN
;
Chenmiao LIU
;
Jinyong XU
;
Qing Cong PAN
;
Dong MENG
Author Information
1. 天津医科大学代谢病医院卫生和计划生育委员会激素与发育重点实验室
- Keywords:
Diabetes mellitus;
Peripheral neuropathy;
Epalrestat;
Nerve conduction
- From:
China Modern Doctor
2014;(26):55-57
- CountryChina
- Language:Chinese
-
Abstract:
Objective This study observed the clinical curative effects of aldose reductase inhibitor epalrestat in treat-ment of diabetic sensory neuropathy. Methods Thirty-four diabetic sensory neuropathy patients were selected. The nerve electrophysiological data were collected before and after treating with epalrestat. Results The ratios of nerve con-ductive velocity in peroneal nerve sensory showed slowing down than normal before and after the treatment, which were respectively 61% and 32%; The ratios of the nerve conductive velocity in tibial nerve sensory nerve segment 1 showed slowing down before and after the treatment,which were respectively 97% and 65%; The nerve conductive velocity of the peroneal sensory nerve after treatment was significantly faster than that before treatment, the nerve conductive ve-locity of the the tibial nerve sensory nerve motion segments in 1 after treatment was significantly faster than that before treatment. Conclusion Epalrestat is one of the effective methods in the treatment of diabetic peripheral neuropathy.
