Control study of autologous stem cell transplantation action glycemic con-trol in patients with type 1 diabetes
- VernacularTitle:自体造血干细胞移植对1型糖尿病患者血糖控制作用的对照研究
- Author:
Tao HOU
1
;
Yuankai SHI
Author Information
1. 中国医科大学绍兴医院血液内科
- Keywords:
Type 1 diabetes;
Autologous hematopoietic stem cell transplantation;
Glucose monitoring;
Insulin
- From:
China Modern Doctor
2014;(26):34-37
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare autologous stem cell transplantation and insulin action glycemic control in patients with type 1 diabetes. Methods A total of 40 patients with newly diagnosed type 1 diabetes patients were divided into transplantation group of 15 patients and 25 cases of insulin groups accorded to treatment, transplantation group treated with autologous hematopoietic stem cell transplantation, insulin group with conventional insulin injection therapy, fol-low-up of > 12 months, 12 months after treatment the adoption of continuous glucose monitoring and evaluation of glycemic control was evaluated. Results Transplantation group after treatment, MBG, LAGE were significantly lower than before treatment (P<0.05), after treatment, transplantation group MBG, SDBG, LAGE, MAGE were significantly lower than insulin group (P<0.05). After the transplant group therapy significantly reduced HbA1c compared with be-fore treatment and significantly lower than in the insulin group(P<0.05), group 2 patients transplanted insulin were de-activated in 9.3,11.2 months, an average reduction of insulin (53.28±21.29)%, after treatment, the amount of insulin significantly reduced transplant group and significantly lower than the insulin group (P<0.05), post-transplant group therapy blood glucose <3.9 mmol/L percentage of time, blood glucose > 11.1 mmol/L percentage of time were signifi-cantly lower than before treatment, and significantly lower than insulin, glucose (3.9~11.1) mmol/L percentage of time increase in the percentage of time now compared to before treatment, and significantly higher than that in the insulin group (P<0.05). All patients with severe adverse reactions occur. Conclusion Compared to conventional insulin injec-tion therapy, autologous hematopoietic stem cell transplantation can effectively control blood sugar with type 1 diabetes, can reduce blood sugar fluctuations, reduce insulin dependence.
