FTO polymorphisms associated with metabolic components in Chinese obese children
- VernacularTitle:中国肥胖儿童FTO基因多态性与肥胖儿童代谢组分关联研究
- Author:
Hong CHEN
1
;
Kana WANG
;
Linxiu TU
;
Weifen ZHU
;
Chunlin WANG
;
Li LIANG
Author Information
1. 浙江大学医学院附属第一医院
- Keywords:
FTO;
Gene;
Obesity;
Insulin resistance;
Child
- From:
China Modern Doctor
2014;(26):24-27
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate whether FTO gene SNP polymorphisms were associated with metabolic traits in Chinese children. Methods A total of 595 children aged between 6 and 17 years were enrolled. The five common SNPs in the FTO gene(rs1421085,rs17817449,rs8050136,rs3751812 and rs9939609)were genotyped. Metabolic compo-nents and insulin were measured. Results (1)The obese patients showed the components of the metabolic traits were significant difference compared to control group.(2)The allele frequency and the genotype distribution of the five SNPs were significant differences between two groups. Minor allele carriers of the five SNPs were associated with increased risks of childhood obesity compared with the wild-type genotype. (3)After adjustment of age, sex and BMI-z score,all of the five SNPs showed a trend towards higher SBP. In addition, rs3751812 and rs8050136 showed significant as-sociation with LDL-C and HOMA-IR levels. Conclusion The five common SNPs in the FTO gene contributes to the e-tiology of obesity and hypertension. The FTO gene polymorphisms (rs3751812 and rs8050136)are found to be associ-ated with increased insulin resistance and plasma LDL levels.
