Effect of mulberry flavone on liver PPARγ in type 2 diabetic rats with simple fatty liver
- VernacularTitle:桑叶黄酮对2型糖尿病并发单纯性脂肪肝大鼠肝组织PPARγ的影响
- Author:
Chengjing XUE
1
;
Yanhui SU
;
Yazhou WANG
;
Hui LI
;
Tingting MA
;
Qiu CHEN
Author Information
1. 山东省枣庄市薛城区人民医院内三科
- Keywords:
Mulberry flavone;
Type 2 diabetes;
Fatty liver;
PPARγ;
Insulin resistance
- From:
China Modern Doctor
2014;(26):1-4
- CountryChina
- Language:Chinese
-
Abstract:
Objective To establish type 2 diabetic rats with simple fatty liver model,observed the efficacy effect of mulberry flavone on rat liver PPARγ,and to explore the possible molecular mechanism of fatty liver and how mulberry flavone improves insulin resistance. Methods Rats were fed with high-fatty diet,then small doses of streptozotion (STZ) were injected intraperitoneally to type 2 diabetic rats with simple fatty liver model. Then part of the rats were fed with mulberry flavone and rosiglitazone. The fasting blood glucoses, fasting insulins and PPARγ were measured.Then ob-served the variety of PPARγ in rat liver. Results ①Compared with normal group (NOR),insulin sensitivity indexes were significantly lower in model group (MOD),but it was increased in mulberry flavone (MLF) and rosiglitazone group (RGZ),and there was no significant difference between MLF and RGZ.②Compared with NOR group, the PPARγof rat liver were significantly reduced in MOD,and increased in MLF and RGZ, but also it had no significant difference be-tween MLF and RGZ. Conclusion Mulberry flavone can improve insulin sensitivity in type 2 diabetic rats with simple fatty liver, also can improve insulin resistance, and this effect is possible related about the increased PPARγof rat liver.
