Study on the efficacy and safety of topiramate combined with sodium val-proate for refractory epilepsy
- VernacularTitle:托吡酯联合丙戊酸钠对难治性癫痫的疗效和安全性研究
- Author:
Weicong ZHENG
1
Author Information
1. 广东省广宁县中医院急诊科
- Keywords:
Topamax;
Sodium valproate;
Refractory epilepsy;
Clinical efficacy;
Safety
- From:
China Modern Doctor
2014;(25):35-37
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the efficacy and safety of topamax combined with sodium valproate for treatment of refractory epilepsy. Methods A total of 110 cases of refractory epilepsy admitted and treated in our hospital from May 2010 to April 2013 were selected and randomly assigned to the observation group and the control group. The observa-tion group(55 cases) was treated by topiramate combined with sodium valproate and the control group (55 cases)was treated by topiramate alone. The clinical efficacy, EEG change and incidence of adverse reactions were compared be-tween the two groups. Results The total cases with therapeutic effectiveness were 49 in the observation group with total effectiveness rate of 89.09%. The total cases with therapeutic effectiveness were 41 in the control group with total effec-tiveness rate of 74.55%. The two groups had statistical difference in total effectiveness rate (P<0.05). The observation group and the control group also had statistical difference in excellent effectiveness rate and ineffectiveness rate (χ2=3.9111, P<0.05). 7 cases of adverse reactions were observed in the two groups during treatment, with incidence of 6.36%, including dizziness, headache, fatigue, anorexia, nausea and vomiting. The adverse reactions were gradually remitted with progress of treatment. No severe adverse reactions were observed, including rash, damage of liver, kid-ney or other important organs. The two groups were comparable in the incidence of adverse reactions,without statistical difference. Conclusion Topamax combined with sodium valproate has good efficacy for treatment of refractory epilepsy,which is worthy of clinical promotion.
