The influence of ulinastatin on body inflammatory factor levels in patients with severe burns
- VernacularTitle:乌司他丁对重度烧伤患者炎症因子水平的影响
- Author:
Cui CHEN
1
;
Youfen FAN
;
Lihua FAN
;
Chun ZHANG
;
Tianbin WU
Author Information
1. 宁波市第二医院烧伤科
- Keywords:
Ulinastatin;
Severe burns;
Inflammatory factor
- From:
China Modern Doctor
2014;(25):32-34
- CountryChina
- Language:Chinese
-
Abstract:
Objective To research the influence of ulinastatin on body inflammatory factor levels in patients with severe burns, and provide the basis treatment of patients with severe burns. Methods A total of 94 patients from Jan 2010 to June 2013 were studied in this test. The control group was treated with basic therapy including fluid infusion, antishock, cutting scab surgery and early nutrition support while the treatment group was received ulinastatin on the basic of control. Routine blood, body inflammatory factors level change and APACHE II score were compared between the two groups, Results The number of WBC and neutrophil in treatment group was higher than control 1group (P <0.05), while the PLT was lower than control group (P<0.05). The APACHE II score was in the same level between the two groups before treatment, while the score of treatment group was obvious lower than control control group after 72hr (P<0.05). The TNF-α and IL-6 in treatment group was lower than control wihle the IL-2 and IL-10 was higher than control(P<0.05). Conclusion Ulinastatin played an important role in improving the patient's body state of inflammation, the patient's symptom and preventing complications.
