The level of CD4+CD25+regulatory T cells and its clinical significance in children with asthma
- VernacularTitle:哮喘患儿外周血CD4+CD25+调节性T细胞的测定及临床意义
- Author:
Jieyi ZHAN
1
;
Huimin LU
;
Suiling LIN
Author Information
1. 广州医科大学附属第一医院儿科
- Keywords:
Asthma;
Children;
Regulatory T cell;
Flow cytometry
- From:
China Modern Doctor
2014;(25):10-12
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the proportion change of CD4+CD25+regulatory T cells (Treg) in peripheral blood of children with asthma and to analyze its significance. Methods A total of 150 asthmatic children were divided into three groups according to their clinical features50 subjects in acute asthma attack group, 50 subjects in clinical re-mission of asthma group and 50 subjects in cough variant asthma group,meanwhile, 50 healthy children were enrolled in the control group. The levels of CD4+CD25+Treg in peripheral blood of all children were detected by flow cytometer. Results The CD4+CD25+Treg level in acute attack group were lowest of the four groups (P<0.05), but the level in the control group was not significantly different from the clinical remission group and the cough variant asthma (all P>0.05). Conclusion The CD4+CD25+regulatory T cells may be involved in the pathogenesis of asthma,the level of CD4+CD25+regulatory T cells correlated with the severity of asthma in children.
