Efficacy of tamsulosin sustained release capsules combined with maximal androgen blockade in treatment of advanced prostate cancer concurrent with bladder outlet obstruction
- VernacularTitle:坦洛新缓释胶囊联合全雄激素阻断治疗晚期前列腺癌伴膀胱出口梗阻的疗效
- Author:
Gang JIN
1
;
Zihua HAN
;
Guanfu WANG
Author Information
1. 浙江省平湖市第一人民医院泌尿外科
- Keywords:
Prostate cancer;
Bladder outlet obstruction;
Tamsulosin sustained release capsules;
Maximal androgen blockade
- From:
China Modern Doctor
2014;(24):37-39
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the efficacy of tamsulosin sustained release capsules combined with maximal an-drogen blockade in the treatment of advanced prostate cancer concurrent with bladder outlet obstruction. Methods Six-ty-eight patients with advanced prostate cancer concurrent with bladder outlet obstruction were randomly divided into the observation group and the control group. Both groups received maximal androgen blockade treatment, on the basis of which the observation group received oral tamsulosin sustained release capsules 0.2 mg and once a day. The treat-ment course was 4 months for two groups. Results After 4 months of treatment, QOL and Qmax of two groups elevated significantly than before treatment, and IPSS score, RU and TPSA reduced significantly than before treatment(P<0.05 or P<0.01). And the improvement degrees of IPSS, QOL, Qmax and RU of the observation group were significantly better than those of the control group (P<0.05). No obvious drug adverse reactions occurred in the control group and 1 case of mild positional dizziness occurred in the observation group. Conclusion In the treatment of patients with advanced prostate cancer, tamsulosin sustained release capsules combined with maximal androgen blockade can rapidly improve the patients' LUTS symptoms, improve the patients' quality of life, and is safe and economical.
