The expression of p53,Ki-67 in colorectal adenocarcinoma with neuroen-docrine differentiation and the correlation between the expression and its prognosis
- VernacularTitle:伴神经内分泌分化结直肠腺癌中p53、Ki-67的表达及其与预后的关系
- Author:
Haiyong ZHANG
1
;
Xiufang LI
;
Yanting LV
;
Mengjun HU
Author Information
1. 浙江省诸暨市人民医院病理科
- Keywords:
Colorectal adenocarcinoma;
Neuroendocrine differentiation;
Immunohistochemistry;
p53;
Ki-67;
Prognosis
- From:
China Modern Doctor
2014;(24):15-18,21
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of p53, Ki-67 in colorectal adenocarcinoma with neuroendocrine differentiation (NED), and to explore the correlation between the expression and its prognosis. Methods The expression of NSE, CgA, Syn, CD-57, p53, Ki-67 in 65 colorectal adenocarcinoma were determined by using immunohistochemi-cal staining. According the neuroendocrine index, 65 cases were divided into two groups,NED positive group(35 cases) and NED negative group (30 cases),and analyzed the influence of erpression of p53, ki-67cm prognosis. Results The positive expression rates of p53, Ki-67 in NED positive group were higher than those in NED negative group (P<0.05). The expression of p53,Ki-67 in NED positive group were significantly associated with lymph node metastasis, differen-tiation and DUCK stages (P<0.05). The 5-year survival rate of NED negative group was obviously higher than that of NED positive group (P<0.05);In NED positive group, the 5-year survival rate of p53 negative and Ki-67 negative ex-pression were significantly higher than that of p53 positive and Ki-67 positive expression (P<0.05). Using Cox regres-sion, lymph node metastasis, differentiation, DUCK stages and the expression of p53,Ki-67 were strong independent prognostic factors for five years of disease-free survival rate of colorectal adenocarcinoma with NED patients (P<0.05). Conclusion The high expression of p53, Ki-67 may be associated with colorectal adenocarcinoma with NED and play an important role in malignant proliferation. p53,Ki-67 are valuable prognostic factors for colorectal adenocarcinoma with NED patients.
