Expression of livin and beclin1 in epithelial ovarian cancer and its rela-tions with tumor invasion and metastasis
- VernacularTitle:Livin、Beclin1在上皮性卵巢癌中的表达及与肿瘤侵袭转移的关系
- Author:
Liqin JIANG
1
;
Jing ZHOU
;
Weizheng HUANG
Author Information
1. 深圳市南山区蛇口人民医院妇产科
- Keywords:
Epithelial ovarian cancer;
Livin;
Beclin1;
Immunohistochemistry
- From:
China Modern Doctor
2014;(23):135-137
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the expression of Livin and Beclin1 in epithelial ovarian cancer and their relations with tumor invasion and metastasis. Methods A total of 65 patients with epithelial ovarian cancer who were admitted and treated in our hospital and Jilin University Affiliated Hospital, plus 15 blocks of normal ovarian tissue samples were selected. Excised ovarian tissues were tested via immunohistochemistry to test the protein expression of Livin and Beclin1, and their relations with tissue differentiation of ovarian cancer, lymphatic metastasis and clinical staging were analyzed. Results Positive rate of expression of Livin, rare expression in normal ovarian tissues (6.7%), and the highest expression rate in tissues of ovarian cancer (68.6%);Positive rate of expression of Beclin1,the highest expression rate in normal ovarian tissues (93.3%) and the lowest in tissues of ovarian cancer (37.1%). Tissue differentiation of ovarian cancer, lymphatic metastasis and clinical staging were interrelated with the expression degree of Livin and Beclin1 (P<0.05). Conclusion Expression of Livin and Beclin1 in epithelial ovarian cancer and tumor invasion and metastasis plays an important role and may become a new target in the treatment of ovarian cancer.
