An analysis of the curative effect of saccharomyces boulardii combined with a standard triple therapy in the treatment of 55 cases of helicobacter pylori-induced peptic ulcer
- VernacularTitle:布拉酵母菌联合标准三联疗法治疗幽门螺杆菌消化性溃疡55例效果分析
- Author:
Luping ZHU
1
;
Fei XIAO
Author Information
1. 河南省疾病预防控制中心门诊部药房
- Keywords:
Saccharomyces boulardii;
Standard triple therapy;
Helicobacter pylori;
Peptic ulcer
- From:
China Modern Doctor
2014;(23):25-27
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the clinical effect and safety of saccharomyces boulardii combined with a standard triple therapy in the treatment of helicobacter pylori-induced peptic ulcer. Methods A total of 109 patients who were diagnosed as helicobacter pylori-induced peptic ulcer were randomly assigned to control group and experimental group. The control group of 54 patients received a standard triple therapy, and the experimental group of 55 patients received saccharomyces boulardii combined with a standard triple therapy. Ulcer recovery, clearance rate of helicobacter pylori and adverse events were observed between the two groups. Results The total effective rate of ulcer recovery in the ex-perimental group was 92.73%, significantly higher than that of 79.63%in the control group(P<0.05); The clearance rate of helicobacter pylori in the experimental group was 90.91%, significantly higher than that of 75.93% in the control group (P<0.05); The incidence of adverse events in the experimental group was 12.73%, and P value was over 0.05 compared to that of 11.11% in the control group. Conclusion The saccharomyces boulardii combined with a standard triple therapy in the treatment of helicobacter pylori-induced peptic ulcer has a significantly effect, and is able to en-hance the clearance rate of helicobacter pylori and the curative effect via a rapid recovery of the dynamic equilibrium of intestinal flora, and an inhibition of the gastric epithelial value and growth of helicobacter pylori.
