Influence of different surgical methods on platelet activation indicators and cerebral angiospasm status of patients with severe craniocerebral in-jury
- VernacularTitle:不同术式对重型颅脑损伤患者血小板活化指标及脑血管痉挛状态的影响观察
- Author:
Changping XU
1
Author Information
1. 河南省安阳市中医院神经外科
- Keywords:
Severe craniocerebral injury;
Small bone window craniotomy;
Standard large trauma craniotomy;
Cere-bral vasospasm;
Platelet activation
- From:
China Modern Doctor
2014;(23):10-12
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the influences of standard large trauma craniotomy and small bone window cranioto-my on the platelet activation indicators and cerebral angiospasm status of the patients with severe craniocerebral injury. Methods Eighty-nine patients with severe craniocerebral injury treated in our hospital from May 2012 to June 2013 were selected and divided into the small bone window craniotomy group(included 44 patients receiving small bone win-dow craniotomy)and the large trauma craniotomy group(included 45 patients receiving standard large trauma cranioto-my). The influences of different surgical methods on the platelet activation indicators and cerebral angiospasm status of the patients with severe craniocerebral injury were observed. Results The levels of postoperative platelet activation in-dicators of both groups increased to varying degrees (CD62p, CD63, GPIIb/Ⅲa, PAgT), but the postoperative platelet activation indicator level of the large trauma craniotomy group was significantly lower than that of the small bone window craniotomy group(P<0.05 or P<0.01). The incidence of cerebral angiospasm of the large trauma cranioto-my group was 6.67% (3/45), which was significantly lower than the 22.73% (10/44) of the small bone window cran-iotomy group (P<0.05). Conclusion The application of standard large trauma craniotomy in the patients with severe craniocerebral injury can effectively reduce the platelet activation indicators and improve the cerebral angiospasm,and have more ideal clinical effects than small bone window craniotomy, thereby worthy of further clinical exploration of surgical procedures and surgical effects.
