Research of MTHFD1 gene polymorphism with genetic susceptibility to colorectal cancer
- VernacularTitle:MTHFD1基因多态性与大肠癌遗传易感性的研究
- Author:
Yong PENG
1
;
Jianhua CUI
;
Xinhua ZHAO
;
Shifeng ZHANG
;
Ximei ZHANG
;
Yafang LI
;
Qionghui WU
Author Information
1. 湖南中医药大学附属宁乡县人民医院肿瘤内科
- Keywords:
Methylenetetrahydrofolate;
Folic acid dehydrogenase;
Gene polymorphism;
Colorectal cancer;
Susceptibility
- From:
China Modern Doctor
2014;(23):1-3
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the correlation of MTHFD1 gene polymorphism with genetic susceptibility to colorec-tal cancer. Methods Ninety-six cases of colorectal cancer patients and 96 cases of healthy controls were investigated by questionnaire, the polymerase chain reaction - restriction fragment length polymorphism (PCR-RFLP) detection method was applied. Results Compared with normal control group, MTHFD1 G1958A polymorphism rs2236225 locus allele frequencies of patients with colorectal cancer had significant difference(P<0.05);rs2236225 genotype risk of col-orectal cancer increased 1.6 times(OR=1.603, 95%CI=0.331~2.534, P<0.05). Conclusion MTHFD1 gene polymorphism is closely related to the susceptibility of colorectal cancer, the main course of colorectal cancer is the rs2236225 gen changes in G1958A site of MTHFD1.
