Efficacy of amlodipine combined irbesartan in treatment of essential hy-pertension

VernacularTitle:氨氯地平联合厄贝沙坦治疗原发性高血压的疗效观察
Author: Fuchen ZHANG ¹
Author Information

1. 山东省烟台芝罘医院药剂科
Keywords: Essential hypertension; Amlodipine; Irbesartan; Joint
From: China Modern Doctor 2014;(20):127-128,131
CountryChina
Language:Chinese
Abstract: Objective To investigate the efficacy of irbesartan combined amlodipine in treatment of essential hyperten-sion. Methods A total of 100 cases essential hypertension in our hospital were randomly divided into study group and the control group, 50 cases in each group, the study group were given irbesartan(Upway) 150mg/d orally, amlodipine (Norvasc)5 mg/d orally; control group were given 150 mg/d orally. The total treatment course were 8 weeks. Results (1)The study group and the control group of patients with SBP, DBP after treatment was significantly lower than before treatment, after treatment, SBP and DBP of study group was improved than the control group more significant, the dif-ference was statistically significant. (2)The total efficiency of study group and the control group respectively was 95.0%, and 80.0%, the difference was statistically significant between the two groups (χ2=4.923, P<0.05) after treatment. (3)Ad-verse reactions: During the two groups of patients showed no abnormal kidney function. Conclusion Amlodipine com-bined with irbesartan in treatment of essential hypertension has significant effect and safety, should be popularized and applied.