Observation on clinical efficacy of entecavir combined with danshen drip-ping pill for the treatment of chronic hepatitis B with hepatic fibrosis
- VernacularTitle:恩替卡韦联合复方丹参滴丸治疗慢性乙型肝炎肝纤维化的临床研究
- Author:
Jianhong ZHANG
1
;
Xianfang GUO
Author Information
1. 新疆军区总医院消化科
- Keywords:
Entecavir;
Danshen dripping pill;
Chronic hepatitis B;
Hepatic fibrosis
- From:
China Modern Doctor
2014;(20):49-51
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical efficacy of entecavir combined with danshen dripping pill for the treatment of chronic hepatitis B with hepatic fibrosis. Methods A total of 46 cases of chronic hepatitis B with hepatic fibrosis in our hospital were randomly divided into control group and observation group. The control group were treated with entecavir. The observation group were treated with entecavir combined with danshen dripping pill.The HBV-DNA negative rate, serum fibrosis markers (Serum HA,LN,PCⅢ,CⅣ) before and after treatment of two groups were com-pared. Results The HBV-DNA negative rate of observation group was 95.7%, which was significantly higher than 65.2% of control group (P<0.05). The serum fibrosis markers of two groups before treatment had no significant differ-ence(P>0.05). Serum HA,LN,PCⅢ,CⅣlevels of observation group after treatment were significantly lower than control group(P<0.05). Conclusion Entecavir combined with danshen dripping pill treatment for chronic hepatitis B with hep-atic fibrosis has exact effect. It can effectively reduce inflammatory activity,improve microcirculation and slow fibrosis down. It’s worthy of clinical widely used.
