Efficacy and effects on hormone levels of radiofrequency ablation com-bined with mifepristone in the treatment of uterine fibroids
- VernacularTitle:自凝刀射频消融术联合米非司酮治疗子宫肌瘤的疗效及对性激素水平的影响
- Author:
Guibing CHEN
1
;
Yilan CHENG
;
Lijun DENG
Author Information
1. 广州市南沙区东涌医院妇产科
- Keywords:
Radiofrequency ablation;
Mifepristone;
Uterine myoma;
Sex hormone
- From:
China Modern Doctor
2014;(20):44-46
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the efficacy on hormone levels of radiofrequency ablation combined with mifepristone in the treatment of uterine fibroids. Methods A total of 126 patients in our hospital of uterine fibroids were divided into two groups, study group with 63 cases were given radiofrequency ablation therapy after mifepristone orally; Control group with 63 cases were given underwent radiofrequency ablation in the treatment of patients , the efficacy and sex hormones of follicle stimulating hormone (FSH), luteinizing hormone (LH), progesterone (P), estradiol (E2) were compared. Results After radiofrequency ablation combined with mifepristone treatment , clinical efficacy rate was 98.41%, significantly higher than the control group, and FSH, LH, P, E2 levels of two groups were significantly different (P<0.05), in which P, E2 were significantly lower than the control group after treatment, the study group;uterine fibroid volume than before treatment significantly reduced , and obviously less than that of the control group , the tumor size was also higher than that in control group (P < 0.05); study group patients with adverse drug reaction light, only 1 cases of nausea, 2 cases of mild dizziness symptoms, patients in the two groups are no adverse reaction rate shows no statistical difference between significance(P>0.05). Conclusion The efficacy of radiofrequency ablation combined with mifepristone in the treatment of uterine fibroids significantly , and its mechanism may be through decreasing serum P, E2 levels and reducing myoma volume of uterine fibroids disappeared.
