Impact of early onset intrahepatic cholestasis of pregnancy on maternal and perinatal infant
- VernacularTitle:早发妊娠期肝内胆汁淤积症对产妇及围产儿预后的影响
- Author:
Jiali WENG
1
;
Weishe ZHANG
Author Information
1. 浙江省丽水市妇幼保健院产科
- Keywords:
Intrahepatic cholestasis of pregnancy;
Total bile acids;
Perinatal infant;
Pregnancy outcomes;
Fetal damage
- From:
China Modern Doctor
2014;(20):1-4
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the impact of early onset of intrahepatic cholestasis of pregnancy on maternal and fetal umbilical artery blood biochemical parameters, and the effects of perinatal infant prognosis. Methods Pregnancy before 28 weeks 45 cases of the disease were acted as early-onset group, 163 cases of the disease after 28 weeks of pregnancy as late-onset group, 100 cases of single pregnancy health pregnant women were chose as control group. Results The serum TBA, TBIL, DBIL, CG, ALT, AST levels and the disease severity of three groups were statistically significant (P <0.05). The serum TBA, TBIL, DBIL, CG, ALT, AST of three groups were statistically significant (P <0.05). Umbilical artery serum TBA, NSE, cTnI, lactic acid, pH value of three groups were statistically significant (P <0.05). Maternal serum and neonatal serum TBA umbilical artery, NSE, cTnI were positively correlated(P <0.05). Early-onset group had worse prognosis late-onset group (P<0.05). Conclusion Pregnancy 28 weeks pregnant before the onset of intrahepatic cholestasis of more serious illness, the impact on biochemical indicators of more significant biochemical parameters before delivery after treatment, although improved, but still significantly affect fetal umbilical artery injury-related indicators such as NSE, cTnI, lactate levels, with higher premature birth rate, poorer prognosis of perinatal children.
