Effects of flurbiprofen on tourniquet-induced lower extremity ischemia-reperfusion injury
- VernacularTitle:氟比洛芬酯对止血带诱发下肢缺血再灌注损伤的影响
- Author:
Yingying LOU
1
;
Zhiqun LIU
;
Lun WU
;
Shengwei LU
Author Information
1. 广东省中山市中医院麻醉科
- Keywords:
Flurbiprofen;
Tourniquet;
Lower extremity;
Ischemia-reperfusion injury
- From:
China Modern Doctor
2014;(18):65-67,70
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effects of flurbiprofen on tourniquet-induced lower extremity ischemia-reperfu-sion (I/R) injury. Methods Ninety ASA I or II patients, aged 30-59 years, scheduled for elective orthopedic operation on CSEA,were randomly assigned into 3 groups (n=30 each):control group (group C),low dose flurbiprofen (group D1) and flurbiprofen (group D2). A tourniquet was applied after affected limb blood droved and inflated (80kPa) and dura-tion of less than 90 min. Patients in group D1 were infused flurbiprofen 1mg/kg slowly on 10 min before the tourniquet inflated and patients in group D2 infused flurbiprofen 2mg/kg. Patients in group C received normal saline 5mL.Blood samples were taken before operation (T0) and taken 30min(T1),2h(T2) after tourniquet release to determine the plasma concentrations of MDA, SOD, TNF-α,IL-6,IL-8.Results The plasma concentrations of MDA, SOD, TNF-α,IL-6,IL-8 in these three group was lower at T1 and T2 than it at T0(P<0.05). The plasma concentrations of MDA, SOD, TNF-α, IL-6,IL-8 in group D1and D2 was lower at T1 and T2 than it at T0(P <0.05). The plasma concentrations of MDA was lower at T2 than it at T1(P<0.05). Conclusion Flurbiprofen can reduce inflammation on tourniquet-induced lower ex-tremity ischemia-reperfusion injury.
