Optimization of technological conditions for synthesis of carbidopa
- VernacularTitle:卡比多巴的合成工艺优选
- Author:
Wei MIN
1
;
Haiping WANG
;
Guangen PAN
Author Information
1. 杭州师范大学医学院附属余杭医院药剂科
- Keywords:
Carbidopa;
Synthesis process;
Orthogonal design
- From:
China Modern Doctor
2014;(18):58-59,62
- CountryChina
- Language:Chinese
-
Abstract:
Objective Optimization the demethylation reaction conditions in the process of synthesizing carbidopa, to determine the optimal production process. Methods With methyldopa as raw material, by methylation,amidation,fol-lowed degradation,demethylation,and then to obtain carbidopa. In the last step of demethylation reaction,with car-bidopa yield as the evaluation index,using four factors and three levels orthogonal design,to optimize the process con-ditions. Results The optimal process conditions for demethylation that is to add 10-fold amount of 36%(g/mL) hy-drochloric acid, and the reaction is remained for 3.5 hours. Conclusion The optimum process is simple,economical, reasonable and convenient for controlling. This study provide experimental basis for industrial production.
