Clinical research of memantine and donepezil on the treatment of moder-ate and severe Alzheimer ’s disease
- VernacularTitle:盐酸美金刚联合多奈哌齐治疗中、重度阿尔茨海默病的临床研究
- Author:
Qu MI
1
;
Yongchang DIWU
Author Information
1. 浙江省湖州市第三人民医院精神科
- Keywords:
Memantine;
Donepezil;
Alzheimer′s disease
- From:
China Modern Doctor
2014;(18):42-44,47
- CountryChina
- Language:Chinese
-
Abstract:
Objective To discuss the effects and security of memantine and donepezil in the treatment of moderate to severe Alzheimer’s disease(AD). Methods Eighty-six AD patients were randomly divided into two groups, the obser-vation group was treated by memantine and donepezil, while the control group was treated by donepezil. The mini-mental state examination (MMSE), ADAS-cog, ADL, NPI were used to evaluate the clinical effects before and after treatment 24 weeks. Results The scores of ADAS-cog,ADL,NPI and MMSE were great significant(P<0.01) in two groups before and after the treatment, the changes of NPI scores in the observation group were significantly higher than in control group (P<0.05),but the adverse reaction of two groups had no significantly difference(P>0.05). Conclusion Both of the two groups have clinical effect on treatment of AD,but memantine and donepezil is better efficacy than donepezil in NPI, and they are all safe.
