The Effects of Intravenous Adenosine Infusion on Intraoperative Remifentanil Requirements and Postoperative Pain in Elective Tonsillectomies Are Influenced by the Time of Day the Operation Is Performed.
10.3344/kjp.2009.22.2.135
- Author:
Cheol LEE
1
;
Kyu Chang LEE
;
Hye Young KIM
;
Jong Min BAHN
;
Eun Kyung CHOI
;
Myeong Jong LEE
Author Information
1. Department of Anesthesiology and Pain Medicine, Chungju Hospital, School of Medicine, Konkuk University, Chungju, Korea. gooddr21@naver.com
- Publication Type:Original Article ; Randomized Controlled Trial
- Keywords:
adenosine;
chronobiology;
postoperative pain;
remifentanil
- MeSH:
Adenosine;
Analgesia;
Anesthesia;
Humans;
Intraoperative Period;
Operating Rooms;
Pain, Postoperative;
Piperidines;
Tonsillectomy
- From:The Korean Journal of Pain
2009;22(2):135-140
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: The chronobiology of postoperative pain is an interesting topic. This study was performed to evaluate the effects of adenosine on inta-operative remifentanil requirements and on postoperative pain in patients undergoing tonsillectomies and how those effects change with changing time of day the surgery is performed. METHODS: For this study, 120 patients were randomly allocated into four groups. Patients in groups B and D received adenosine at a dose of 50microgram/kg/min, and those in group A and C received an equal volume of saline from 10 minutes after the induction of anesthesia until the end of surgery. Group A (saline) and B (adenosine) patients entered the operating room after 08:30 and finished before 11:00, Group C (saline) and D (adenosine) patients entered the operating room after 13:30 and finished before 16:00. We evaluated the intraoperative time-weighted mean remifentanil dose, and postoperative pain scores at 1, 6, 12, and 24 hours, and the analgesic dose required during the following 24 hours. RESULTS: Time-weighted mean remifentanil doses during the intraoperative period and the analgesic requirement during the following 24 hours in group D was significantly lower than in the other groups. The numeric rating scale for pain at 1, and 6 hours in group D was significantly lower (P < 0.01) than that of group A. There were no significant differences in side effects among groups. CONCLUSIONS: Use of intraoperative adenosine infusion provides perioperative analgesia. Postoperative pain is affected by the time of day the operation is performed.
