Correlation analysis on serum homocysteine and left ventricular ejection fraction in type 2 diabetes mellitus
- VernacularTitle:2型糖尿病患者同型半胱氨酸与左心室射血分数相关性研究
- Author:
Lili ZHOU
1
;
Shushan ZHAO
;
Ran TAO
;
Xiaojia LOU
Author Information
1. 浙江省东阳市人民医院内分泌科
- Keywords:
Homocysteine;
Type 2 diabetes mellitus;
Left ventricular ejection fraction
- From:
China Modern Doctor
2014;(18):1-3,7
- CountryChina
- Language:Chinese
-
Abstract:
Objective A link between homocysteine (Hcy) and left ventricular ejection fraction(LVEF) emerged from re-cent studies but was yet not explored specifically in type 2 diabetic patients. This study aimed to assess the relationship between LVEF and Hcy in type 2 diabetic patients. Methods A total of 72 type 2 diabetic patients were selected for this study and were divided into two groups (40 examples with coronary heart disease, 32 examples without coronary heart disease) javascript:Serum Hcy,glycosylated hemoglobin,cholesterol(TC) and triglyceride(TG) were analyzed.LVEF was assessed by echocardiography. Results There was no difference in systolic blood pressure, diastolic blood pressure, glycosylated hemoglobin,total cholesterol and triglyceride in two groups of patients (P>0.05);The serum Hcy was obvi-ously higher in type 2 diabetic patients with coronary heart disease compared to those without (P<0.05);Factors signifi-cantly associated with a LVEF<55%were serum Hcy OR=1.211(95%CI 1.041~1.408) in type 2 diabetic patients with coronary heart disease.The serum Hcy had significant negatively correlation with LVEF (r=-0.706,P=0.000) in type 2 diabetic patients with coronary heart disease. Conclusion This study highlights an inverse relationship between Hcy and LVEF in type 2 diabetic patients with coronary artery disease.The serum Hcy is a risk factor associated with a LVEF<55%.
