Effects of Shenfu Injection on the Damage of Kidney with Acute Pan-creatitis in Rats
10.3969/j.issn.1673-9701.2009.18.017
- VernacularTitle:参附注射液对大鼠重症急性胰腺炎肾损伤保护作用的实验研究
- Author:
Yunhai CHU
1
;
Yi WANG
;
Zhanliang HU
Author Information
1. 黑龙江中医药大学附属第一医院
- Keywords:
Severe acute pancreatitis;
Shenfu injection;
Acute kidney injury;
TNF-α
- From:
China Modern Doctor
2009;47(18):41-42,45,封3
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the protective effects of ShenFu injection on kidney of experimental acute pancreatitis in mrs. Methods Twenty and one Wister rats were randomized into the sham-operated group,AP group and Shenfu group. The plasma level of MDA,MPO,SOD,TNF-α and the kidney level of MDA、ON、SOD and historical scores was determined. Results The values of plasma SOD、MDA、MPO、TNF-α and the kidney of MDA、ON and historical scores in Shenfu-gronp were higher than that in the sham-operated group but lower than that in AP group. The values of SOD of plasma and kidney in Shenfu group is higher than that in AP but lower than that in the sharm-operated group. Coneluion Shenfu injection can protect the early injure of kidney of severe acute panereatitis,which mechanism may be to improve the kidney microcirculation,to reduce the production of TNF-α,to decrease the inflammation of plasma and kidney and to decrease the injure of oxygen free radicals.
