Clinical Study of Transarterial Chemoembolization for Primary Hepatic Carcinoma with Lipiodol-arsenic Trioxide Emulsion
10.3969/j.issn.1673-9701.2009.18.014
- VernacularTitle:亚砷酸-碘油乳剂经动脉栓塞治疗原发性肝癌的临床研究
- Author:
Yubin ZHOU
1
;
Danming WU
;
Qingfeng LIU
Author Information
1. 辽宁省人民医院
- Keywords:
Arsenicals/therapeutic use;
Primary hepatic carcinoma;
Transhepatic arterial chemoembelization
- From:
China Modern Doctor
2009;47(18):32-33,49
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the effect and toxicity of lipiodol-arsenic trioxide emulsion on the treatment of primary hepatic carcinoma. Methods Arsenic trioxide 20mg and lipiodol were fully mixtured into lipiodol-arsenic trioxide emulsion,which were injected into hepatic artery by catheters in 58 patients with primary hepatic carcinoma. If the patients' conditions progressed(tumor got larger or AFP increased),Anthracyctine would be used simultaneously. The effect and toxicity were observed. Results After 1～3 times of thera-py only with lipiodol-arsenic trioxide emulsion in all of 58 patients,objective response rate was 20.7% with 12 eases of PR,36 cases of NC and 10 cases of PD. AFP decreased from(11109.36±2920.82) IU/mL to(10001.61±2880.67) IU/mL averagely(P>0.05). An-thracycline was applied in 22 patients,and tumors got smaller in 16 cases after that. AFP decreased from (13901.11±4862.26) IU/mL to(5470.63±2597.79) IU/mL averagely(P< 0.05). The major toxic side effect were pyrexia, nausea and vomiting, pain in hepatic re-gion,mild bone marrow depression and hepatic damage. No irreversible toxic response occurred. Conclusion Lipiodol-arsenic trioxide emulsion injection via hepatic artery by catheters is effective and less toxic to treat primary hepatic carcinoma.
