Change Feature of Blood Serum Zymogram and Prognostic Analysis of 256 Cases of Drug-induced Liver Injury
10.3969/j.issn.1673-9701.2009.17.007
- VernacularTitle:256例药物性肝病血清酶谱学变化特点及预后分析
- Author:
Xuyou LIU
1
;
Tinghua LI
;
Jixiong YANG
;
Yueyong QIU
Author Information
1. 广东省惠东县人民医院
- Keywords:
Drug-induced liver disease;
Blood serum zymogram;
Prognostic marker
- From:
China Modern Doctor
2009;47(17):14-15,28
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the etiology and clinical features of drug-induced liver damage,in order to draw more attention to this problem. Methods Two hundred and fifty-six cases over a 10-year period were retrospectively analyzed. Results A variety of drugs,in-cluding traditional Chinese medicines(23.8% of our total cases)and immunosuppressive agent(11.7%)caused liver damage. The main clinical manifestations of it were fatigue,nausea,vomiting and jaundice. In 78.5% of our cases,the symptoms were relieved or completely disappeared, but there was still 6.6% mortality rate. Conclusion The clinical features of drug-induced liver damage are of no specificity,and the mortality of it is high. Liver function should he monitored when suspected are prescribed.
