Research progress of exosome microneedle drug delivery system
- VernacularTitle:结合外泌体的微针经皮给药系统研究进展
- Author:
Wulong WEN
1
;
Weiye ZHANG
1
;
Xin SUN
1
;
Xiao LIANG
1
;
Jing YANG
2
;
Rui WANG
1
Author Information
1. College of Pharmacy，Heilongjiang University of Chinese Medicine，Harbin 150040，China
2. College of Basic Medicine，Heilongjiang University of Chinese Medicine，Harbin 150040，China
- Publication Type:Journal Article
- Keywords:
microneedle;
exosome;
percutaneous administration;
drug loading system
- From:
China Pharmacy
2024;35(13):1663-1667
- CountryChina
- Language:Chinese
-
Abstract:
Microneedles can penetrate the skin barrier to deliver drugs without touching the nociceptive nerves， to effectively increase the efficiency of transdermal drug delivery and improve patient compliance. Exosomes have multiple physiological functions and good biocompatibility， and are natural nanoscale drug carriers. This paper reviews the pathways and advantages of exosomes combined with microneedles for the treatment of diseases， and describes the current research status of exosome microneedle drug delivery system in various diseases. Exosome microneedles can be divided into two categories： （1） exosomes as therapeutic agents， their unique physiological origin can effectively avoid the toxicity and immunogenicity of conventional drugs and other problems； combined with microneedles directly in the specific medication site can greatly improve the metabolic consumption of oral drug delivery and patient compliance of injection drug delivery. （2） Exosomes as drug carriers， their natural vesicle structure and endogenous characteristics can protect the metabolism of foreign drugs in the body and enhance the targeting； combined with microneedles can effectively solve the problem of transdermal delivery of drugs with high efficacy but poor stability. Exosome microneedle drug delivery system is still in the laboratory stage， but it has shown great development prospects in repairing spinal cord injury， promoting diabetic ulcer wound healing， germinating， intervening myocardial infraction， relieving chronic pain and other diseases.
