Correlation between serum IL-1β,IL-16 levels and negative symptoms in different stages of schizophrenia
10.19405/j.cnki.issn1000-1492.2024.04.023
- VernacularTitle:精神分裂症患者不同阶段血清IL-1β、IL-16水平与阴性症状相关性研究
- Author:
Anzhen WANG
1
;
Xulai ZHANG
;
Fanfan YAN
;
Wenzhi PEI
;
Xialong CHENG
Author Information
1. 安徽医科大学附属心理医院,安徽省精神卫生中心,合肥市第四人民医院,安徽省精神心理疾病临床研究中心焦虑抑郁科,合肥 230031
- Keywords:
schizophrenia;
interleukin-1β;
interleukin-16;
negative symptom
- From:
Acta Universitatis Medicinalis Anhui
2024;59(4):703-708
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the difference of serum inflammatory factors in patients with first episode schizo-phrenia,patients with relapse episode schizophrenia and healthy people,and the correlation between serum inflam-matory factors with negative symptoms in patients with schizophrenia,so as to provide reference for clinical inter-vention.Methods A total of 86 patients with first episode schizophrenia(first episode group),80 patients with re-lapse episode schizophrenia(relapse episode group)and 82 healthy people(control group)were included in the study.The difference of serum inflammatory factors among the three groups and the correlation between serum inflammatory factors with negative symptoms were analyzed.Results There were significant differences in serum interleukin(IL)-1β and IL-16 levels among the three groups(P<0.05).The analysis and comparison between the two groups showed that the serum IL-1β in first episode group was significantly higher than that in relapse episode group and control group(P<0.05),serum IL-16 in first episode group and relapse episode group was significantly higher than that in control group(P<0.05).Serum IL-1β was negatively correlated with PANSS general psycho-pathological scale factor score in first episode group(P<0.05),and serum IL-16 was positively correlated with PANSS negative symptom scale factor score in relapse episode group(P<0.05).IL-16 level might be an inde-pendent risk factor affecting the onset of first episode group and relapse episode group(P<0.05).Conclusion There are differences in serum levels of IL-1β and IL-16 between patients with schizophrenia and healthy people.Serum IL-16 levels in patients with relapse episode schizophrenia are associated with negative symptoms.IL-16 lev-el may be an independent risk factor for schizophrenia.
