Research Progress on Animal Models of Long Bone Fractures
10.12300/j.issn.1674-5817.2023.183
- VernacularTitle:长骨骨折动物模型的研究进展
- Author:
Guangyuan YAO
1
;
Ping DONG
;
Hao WU
;
Mei BAI
;
Ying DANG
;
Yue WANG
;
Kai HU
Author Information
1. 内蒙古医科大学中医学院,呼和浩特 010110
- Keywords:
Experimental animal model;
Fracture healing;
Long bone
- From:
Laboratory Animal and Comparative Medicine
2024;44(3):289-296
- CountryChina
- Language:Chinese
-
Abstract:
Traumatic fractures and stress fractures are common orthopedic diseases,and there is great potential in researching bone turnover,repair,and promotion of fracture healing.Basic medical experiments often use animal models of long bone fractures in limbs to study the mechanisms of various interventions on fracture healing.Fracture healing is a complex process influenced by multiple factors and involves multiple molecules and pathways.Therefore,to explore the mechanisms more deeply,accelerate the translation of results,and improve the clinical efficacy,it is particularly important to choose the appropriate animal fracture modeling methods in experimental research.Based on this,this paper conducts a literature review of animal species and modeling methods commonly used for long bone fracture models in experimental research.It summarizes five methods:bone defect method,physical impact method,mechanical bending method,open osteotomy method,and drilling method.A side-by-side comparison of their advantages,disadvantages,and scope of application is made,aiming to provide suitable fracture models for studyingthe mechanisms of fracture healing interventions.
