Prevalence of Neisseria meningitidis among healthy children and adolescents aged 3-18 in Anhui Province
10.16835/j.cnki.1000-9817.2024167
- VernacularTitle:安徽省3～18岁健康儿童青少年脑膜炎奈瑟菌带菌状况
- Author:
SU Ying, CHEN Xia, WANG Binbing, LUO Xianwei, CHENG Pengbo, ZHOU Shujie
1
Author Information
1. Department of Immunoprophylaxis, Anhui Provincial Center for Disease Control and Prevention, Hefei (230601) , Anhui Province, China
- Publication Type:Journal Article
- Keywords:
Neisseria meningitidis;
Nucleic acid amplification techniques;
Bacterial cultivation;
Child;
Adolescent
- From:
Chinese Journal of School Health
2024;45(6):878-881
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To monitor the prevelance of Neisseria meningitidis among healthy children and adolescents aged 3-18 in Anhui Province, so as to provide support for epidemic cerebrospinal meningitis prevention and control.
Methods:From September to October in 2021 and 2022, 4 033 healthy children and adolescents aged 3-18 were selected by stratified random sampling from Anhui Province, including areas north of the Yangtze River (Bozhou, Fuyang, Bengbu, Huainan, Chuzhou, Hefei) and areas south of the Yangtze River (Wuhu, Maanshan, Tongling, Anqing, Chizhou, Xuancheng) and the secretions of children and adolescents were collected from the posterior pharyngeal wall above the uvula, and the strains were identified by bacterial culture and nucleic acid detection. McNemar test and Kappa consistency test were used for statistical analysis. Chisquare test and Chisquare trend test were used to compare the rates.
Results:The carrier rates of Neisseria meningitidis were 0.47% and 1.07%, respectively. The sensitivity of nucleic acid detection was higher. Among the detected bacteria, group B accounted for the largest proportion of 76.74%. It was followed by group C (4.65%), group Y (4.65%), group W 135 (2.33%) and group X (2.33%). The bacteria bearing rate of male students was higher than that of female students (χ2=11.44); with the increase of age, the bacteria bearing rate of children and adolescents showed an increasing trend (χ2trend=42.69); the bacterial bearing rate of children and adolescents in the north of the Yangtze River was higher than that in the south of the Yangtze River (χ2=23.19); the bacteria bearing rate of children and adolescents without immune history was higher than that with immune history (χ2=11.02)(P<0.01).
Conclusions:Neisseria meningitidis group B has become an epidemic strain in Anhui Province, and senior children and adolescents have become the key population of epidemic prevention and control. It is necessary to continue to do a good job in the surveillance of epidemic cerebrospinal meningitis disease and focuse on group B disease cases, so as to prevent the occurrence of cluster outbreaks in schools.
