Research progress on collection and analysis methods of exhaled volatile organic compounds

Yazhen HE; Rui Gao; Zhijun WU; Jingguang Fan; Chunguang Ding

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Research progress on collection and analysis methods of exhaled volatile organic compounds

VernacularTitle:呼出气挥发性有机物的采集及分析方法研究进展
Author: Yazhen HE ^{1
,

2} ; Rui GAO ^{1
,

2} ; Zhijun WU ³ ; Jingguang FAN ^{1
,

2} ; Chunguang DING ^{1
,

2}
Author Information

1. School of Public Health, Guangdong Pharmaceutical University, Guangzhou, Guangdong 510224, China
2. Research Center for Occupational Safety and Health, National Health Commission, Beijing 102308, China.
3. National Institute for Occupational Health and Poison Control, Chinese Center for Disease Control and Prevention, Beijing 102308, China.
Publication Type:Review
Keywords: exhaled breath; volatile organic compound; collection; enrichment; detection
From: Journal of Environmental and Occupational Medicine 2024;41(6):707-712
CountryChina
Language:Chinese
Abstract: The composition and concentration of volatile organic compounds (VOCs) in exhaled breath are closely related to human health and the analysis of VOCs by collecting human exhaled breath has been widely used in disease surveillance research. This article reviewed the collection, enrichment, and detection methods of exhaled VOCs, which can provide a reference for selecting appropriate technology for follow-up research. The exhaled breath collection devices mainly include sampling bags for mixed exhaled breath and biological volatile organic compound (Bio-VOC) samplers for alveolar air. The pre-enrichment equipment included thermal desorption (TD), solid-phase microextraction device (SPME), and needle trap device (NTD). The detection methods of exhaled VOCs include gas chromatography-mass spectrometry (GC-MS), proton transfer reaction mass spectrometry (PTR-MS), selective ion flow tube mass spectrometry (SIFT-MS), and electronic nose. At present, the collection and enrichment technology of exhaled breath is not mature yet, and its influence on the results of detection is lack of evaluation. In the future, the research on collection and enrichment technology of exhaled breath should be strengthened to further promote the application of exhaled breath in disease surveillance research.