Application of the CRISPR/Cas system in gene editing and nucleic acid detection of parasitic diseases: a review
10.16250/j.32.1374.2024057
- VernacularTitle:CRISPR/Cas系统在寄生虫基因编辑 与核酸检测中的应用进展
- Author:
Shuning YAN
1
;
Shuo YANG
1
;
Hanyin YANG
1
;
Yi XIN
1
;
Bin XU
1
;
Wei HU
1
;
Yan LU
1
;
Bin ZHENG
1
,
2
Author Information
1. National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention (Chinese Center for Tropical Diseases Research), National Health Commission Key Laboratory of Parasite and Vector Biology, WHO Collaborating Centre for Tropical Diseases, National Center for International Research on Tropical Diseases, Ministry of Science and Technology, Shanghai 200025, China
2. School of Global Health, Chinese Center for Tropical Diseases Research and Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
- Publication Type:Journal Article
- Keywords:
CRISPR/Cas system;
Parasitic disease;
Gene editing;
Nucleic acid detection
- From:
Chinese Journal of Schistosomiasis Control
2024;36(3):314-320
- CountryChina
- Language:Chinese
-
Abstract:
CRISPR/Cas system, an adaptive immune system with clustered regularly interspaced short palindromic repeats, may interfere with exogenous nucleic acids and protect prokaryotes from external damages, is an effective gene editing and nucleic acid detection tools. The CRISPR/Cas system has been widely applied in virology and bacteriology; however, there is relatively less knowledge about the application of the CRISPR/Cas system in parasitic diseases. The review summarizes the mechanisms of action of the CRISPR/Cas system and provides a comprehensive overview of their application in gene editing and nucleic acid detection of parasitic diseases, so as to provide insights into future studies on parasitic diseases.
