Fabrication and performance evaluation of high-modulus and high-strength silk fibroin guided bone regeneration membrane
10.19405/j.cnki.issn1000-1492.2024.04.005
- VernacularTitle:高模量高强度丝素蛋白GBR膜的制备及性能评估
- Author:
Xiaoyu LIAO
1
;
Hui FANG
;
Feiyu YANG
;
Duohong ZOU
Author Information
1. 安徽医科大学口腔医学院,安徽医科大学附属口腔医院,安徽省口腔疾病研究重点实验室,合肥 230032
- Keywords:
bone defect repair;
maintaining the space for bone regeneration;
guided bone regeneration mem-brane;
silk fibroin;
evaporation-heat pressing method;
osteogenic differentiation;
tensile strength
- From:
Acta Universitatis Medicinalis Anhui
2024;59(4):590-595
- CountryChina
- Language:Chinese
-
Abstract:
Objective To develop a high modulus and high strength biodegradable silk fibroin GBR membrane to address the issue of maintaining the space for bone regeneration in the repair of osseous defects.Methods After purifying silk fibroin protein,membrane materials were prepared using evaporation-hot pressing method.The physi-cal and chemical properties and biological performance of the membranes were evaluated using stretching tests,in vitro simulations,and cell co-culturing methods.Results A silk fibroin GBR membrane was successfully fabrica-ted,resulting in a simulated degradation rate of 35.3%after 12 h in vitro.The wet-state elastic modulus reached 45 MPa,while the tensile strength reached 8.39 MPa.Furthermore,the cell survival rate was nearly 100%after 7 days.Conclusion The biodegradable GBR membrane produced in this study possesses high modulus and strength,as well as excellent biocompatibility,offering a promise as a foundation for addressing the bone defect re-pair and bone space maintenance.
- Full text:2024070221533901566高模量高强度丝素蛋白GBR膜的制备及性能评估_廖小毓.pdf
