Fabrication and performance evaluation of high-modulus and high-strength silk fibroin guided bone regeneration membrane
10.19405/j.cnki.issn1000-1492.2024.04.005
- Author:
Xiaoyu Liao
1
;
Hui Fang
1
;
Feiyu Yang
1
;
Duohong Zou
1
,
2
Author Information
1. College and Hospital of Stomatology , Anhui Medical University , Key Laboratory of Oral Diseases Research of Anhui Province , Hefei 230032
2. Shanghai Ninth Peoples Hospital , Shanghai JiaoTong University School of Medicine , Shanghai JiaoTong University School of Stomatology , Shanghai Key Laboratory of Stomatology , Shanghai 200011
- Publication Type:Journal Article
- Keywords:
bone defect repair;
maintaining the space for bone regeneration;
guided bone regeneration mem- brane;
silk fibroin;
evaporation-heat pressing method;
osteogenic differentiation;
tensile strength
- From:
Acta Universitatis Medicinalis Anhui
2024;59(4):590-595
- CountryChina
- Language:Chinese
-
Abstract:
Objective :To develop a high modulus and high strength biodegradable silk fibroin GBR membrane to address the issue of maintaining the space for bone regeneration in the repair of osseous defects .
Methods :After purifying silk fibroin protein , membrane materials were prepared using evaporation-hot pressing method . The physi- cal and chemical properties and biological performance of the membranes were evaluated using stretching tests , in vitro simulations , and cell co-culturing methods .
Results :A silk fibroin GBR membrane was successfully fabrica- ted , resulting in a simulated degradation rate of 35 . 3% after 12 h in vitro . The wet-state elastic modulus reached 45 MPa , while the tensile strength reached 8. 39 MPa. Furthermore , the cell survival rate was nearly 100% after 7 days .
Conclusion :The biodegradable GBR membrane produced in this study possesses high modulus and strength , as well as excellent biocompatibility , offering a promise as a foundation for addressing the bone defect re- pair and bone space maintenance .
- Full text:2024070221533901566高模量高强度丝素蛋白GBR膜的制备及性能评估_廖小毓.pdf
