Association of TAZ gene polymorphisms with non⁃cardia gastric cancer
10.19405/j.cnki.issn1000-1492.2023.11.009
- Author:
Qiaoqiao Wang
1
;
Fang Gao
2
Author Information
1. School of Basic Medicine and Forensic Medicine, Baotou Medical College ,Baotou 014040
2. School of Medical Technology and Anesthesiology,Baotou Medical College ,Baotou 014040
- Publication Type:Journal Article
- Keywords:
transcriptional coactivator containing PDZ binding motif ( TAZ);
single nucleotide polymorphisms;
non⁃cardia gastric cancer;
haplotypes;
association study
- From:
Acta Universitatis Medicinalis Anhui
2023;58(11):1854-1858
- CountryChina
- Language:Chinese
-
Abstract:
Objective :To study the association between single nucleotide polymorphism (SNP) in transcriptional
coactivator containing PDZ binding motif (TAZ) gene and the risk of non⁃cardia gastric cancer.
Methods :Among 460 patients with non⁃cardia gastric cancer and 470 normal controls , TAZ rs16861985 , rs1055153 , rs6783790, rs12490239 were genotyped by polymerase chain reaction⁃restriction fragment length polymorphism (PCR⁃RFLP) . Unconditional Logistic regression was used to evaluate the association of studied SNPs with the risk of non⁃cardia gastric cancer.
Results :TAZ rs16861985 was associated with the risk of non⁃cardia gastric cancer, compared with the CC genotype carriers , the carriers of GC genotype had an increased risk of noncardia gastric cancer ( OR =1. 547 , 95% CI: 1. 145 - 2. 089) . TAZ rs1055153 was associated with the risk of non-cardia gastric cancer, compared with the GG genotype carriers , the carriers of GT + TT genotypes had a decreased risk of non-cardia gastric cancer ( OR = 0. 570 , 95% CI: 0. 400 - 0. 814) . TAZ rs6783790 and rs12490239 were not associated with the risk of non⁃cardia gastric cancer. Among the haplotypes constructed by TAZ rs16861985 , rs1055153 , rs6783790 and s12490239 , C ⁃G ⁃A ⁃A haplotype had a decreased risk of non⁃cardia gastric cancer ( OR = 0. 761 , 95% CI: 0. 612- 0. 945) , while G ⁃G ⁃A ⁃G haplotype had an increased risk of non⁃cardia gastric cancer ( OR = 1. 894 , 95% CI:1. 314 - 2. 730) . The fourth⁃order interaction of TAZ rs16861985 , rs1055153 , rs6783790 and rs12490239 was associated with non⁃cardia gastric cancer risk(P < 0. 05) .
Conclusion :TAZ rs16861985 and rs1055153 may play a role in the risk of non⁃cardia gastric cancer. The C ⁃G ⁃A ⁃A haplotype constructed by TAZ rs16861985 , rs1055153, rs6783790 and rs12490239 can reduce the risk of non⁃cardia gastric cancer, and G ⁃G ⁃A ⁃G haplotype can increase the risk of non⁃cardia gastric cancer. The interaction of TAZ rs16861985 , rs1055153 , rs6783790 and rs12490239 has a synergistic effect innon⁃cardia gastric cancer.
- Full text:2024070217271357074TAZ基因多态性与非贲门胃癌的关系_王巧巧.pdf
