Endobronchial Brachytherapy of Advanced Non-small Cell Lung Carcinoma.
- Author:
Won Sup YOON
1
;
Myung Sun CHOI
;
Dae Sik YANG
;
Tae Hyun KIM
;
Chul Yong KIM
Author Information
1. Department of Radiation Oncology, College of Medicine, Korea University, Seoul, Korea. kcyro@korea.ac.kr
- Publication Type:Original Article
- Keywords:
Non-small cell lung carcinoma;
Endobronchial brachytherapy
- MeSH:
Brachytherapy*;
Bronchoscopy;
Cough;
Dyspnea;
Hemoptysis;
Humans;
Lung*;
Neoplasm Metastasis;
Pneumothorax;
Radiation Pneumonitis;
Radius;
Recurrence;
Retrospective Studies
- From:Journal of Lung Cancer
2003;2(2):110-115
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: To evaluate the effect of high-dose-rate endobronchial brachytherapy for symptomatic relief, tumor response and overall survival of advanced non-small cell lung carcinoma (NSCLC). MATERIALS AND METHODS: Between July 1992 and July 2001, 37 patients with advanced NSCLC were analysed retrospectively. Group A patients (palliative aim, n=25) were treated using brachytherapy alone due to relapse after external beam radiation therapy (EBRT). Group B patients (curative aim, n=12) were treated using brachytherapy alone or combined EBRT due to untreated inoperable NSCLC or positive resection margin after radical resection. The dose per fraction was 3~6 Gy at a radius of 1cm from the center of the source and each patient received 2~3 fractions. The total dose of brachytherapy was 9~18 Gy (median 15 Gy). Each fraction separated by 1 week interval. RESULTS: Symptomatic relief was obtained for cough (58.3% & 72.7%), dyspnea (56.3% & 75%) and hemoptysis (86.7% & 100%) in group A and B, respectively. The tumor improvement on bronchoscopy was obtained for complete response (28% & 60%) and partial response (64% & 40%) in group A and B, respectively. Median overall survival was 7 and 17.2 months for Group A and B, respectively. In group A, mediastinal node metastasis (p=0.039) and Karnofsky performance scale (p=0.062) was independent prognostic factor by univariate analysis. After radical therapy, 7 symptomatic radiation pneumonitis, 4 hemoptysis and 1 pneumothorax were observed. CONCLUSION: Endobronchial brachytherapy was effective for symptomatic relief of hemoptysis. In curative aim, we think that survival improvement may be expected in some selected patients
