Chinese Medicine Regulates Hepatocellular Carcinoma-related Signaling Pathways： A Review
10.13422/j.cnki.syfjx.20240128
- VernacularTitle:肝癌相关信号通路的中药调控研究进展
- Author:
Chun YU
1
;
Fen GAO
1
;
Lanlan ZHENG
1
;
Cai GUO
1
;
Yanfang HE
1
;
Jiaojiao XIE
1
;
Xuan ZHANG
1
;
Yanhua MA
1
Author Information
1. First School of Clinical Medicine， Gansu University of Chinese Medicine， Lanzhou 730000， China
- Publication Type:Review
- Keywords:
Chinese medicine;
hepatocellular carcinoma;
signaling pathway;
research progress
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2024;30(15):232-243
- CountryChina
- Language:Chinese
-
Abstract:
Hepatocellular carcinoma （HCC） is a common tumor in the digestive tract， the formation mechanism of which remains to be fully elucidated. Although surgery， radiation， chemotherapy， targeted therapy， and immunotherapy have achieved significant results in the treatment of HCC， these methods are accompanied by a considerable number of adverse reactions and complications. In recent years， Chinese medicine has shown remarkable efficacy in the treatment of HCC， and both basic experiments and clinical studies have confirmed the effectiveness of Chinese medicine， which exerts therapeutic effects via multiple components and multiple targets. However， the pathogenesis of HCC is exceptionally complex and not fully understood， which means that studies remain to be carried out regarding the specific mechanism of Chinese medicine in preventing and treating HCC. Network pharmacology and molecular biology can be employed to decipher the mechanism of Chinese medicine in the treatment of diseases. Studies have shown that Chinese medicine can regulate various pathways such as the mitogen-activated protein kinase （MAPK）， phosphatidylinositol 3-kinase/protein kinase B （PI3K/Akt）， Hedgehog， Wnt/β-catenin， nuclear factor-κB （NF-κB）， Janus kinase 2/signal transducer and activator of transcription 3 （JAK2/STAT3）， and transforming growth factor-β （TGF-β）/Smad signaling pathways. Chinese medicine can exhibit its anti-HCC effects by inducing cell apoptosis， inhibiting cell proliferation and migration， and blocking the cell cycle via the above pathways. However， the specific mechanisms remain to be systematically studied. This study comprehensively reviews the regulatory effects of Chinese medicine on HCC-related signaling pathways to reveal the molecular mechanisms of Chinese medicine in the treatment of HCC. This view holds the promise of providing new targets， new perspectives， and new therapies for HCC treatment and advancing the modernization and development of Chinese medicine.
