Analysis of Animal Models of Hepatic Ascites Based on Clinical Evidence Characteristics of Traditional Chinese and Western Medicine
10.13422/j.cnki.syfjx.20240801
- VernacularTitle:基于中西医临床病证特点的肝硬化腹水动物模型分析
- Author:
Yu HUAN
1
;
Shilei QIN
1
;
Shumei JI
1
;
Shuo NAN
1
;
Yilong HU
1
;
Ting ZUO
1
;
Mingsan MIAO
1
Author Information
1. School of Pharmacy，Henan University of Chinese Medicine，Zhengzhou 450046，China
- Publication Type:Journal Article
- Keywords:
hepatic ascites;
diagnostic criteria;
coincidence;
model analysis
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2024;30(15):200-205
- CountryChina
- Language:Chinese
-
Abstract:
Hepatic ascites is one of the common and difficult complications in the decompensated stage of liver cirrhosis， and its incidence is increasing. In clinical practice， the prognosis of patients with hepatic ascites after surgery is worse， and the disease is recurrent. Traditional Chinese medicine （TCM） has certain advantages in treating hepatic ascites. However， there is no uniform standard for the preparation of animal models of hepatic ascites in accordance with TCM evidence. Therefore， this paper summarized the literature on animal models of hepatic ascites and analyzed the existing animal models of hepatic ascites based on the clinical diagnostic criteria of hepatic ascites in TCM and western medicine. The results show that the commonly used modeling methods for hepatic ascites mainly include the single-factor method， composite factor induction method， surgical method， and immunization method. Most of them are guided by western medicine theories， and their pathogenic mechanisms are mostly consistent with those of western medicine and are different from TCM evidence. Therefore， it is suggested that TCM intervening factors should be imposed in the process of model preparation， so as to prepare an animal model of hepatic ascites that meets the clinical evidence characteristics of TCM and western medicine.
