Structure-activity Omics of Traditional Chinese Medicine： A Case Study of Anti-inflammatory and Analgesic Effect of Qizhi Weitong Granules
- VernacularTitle:中药构效组学——以气滞胃痛颗粒抗炎镇痛作用为例
- Author:
Xiansheng MENG
1
;
Ying ZHENG
1
;
Ying MENG
1
;
Bing QI
1
;
Sicong LIU
1
;
Xi LUO
1
;
Xinpeng QIN
1
;
Yongrui BAO
1
;
Shuai WANG
1
;
Tianjiao LI
1
Author Information
- Publication Type:Journal Article
- Keywords: structure-activity omics; Qizhi Weitong granules; anti-inflammatory and analgesic; structure; target
- From: Chinese Journal of Experimental Traditional Medical Formulae 2024;30(15):129-135
- CountryChina
- Language:Chinese
- Abstract: The complex chemical composition and limited research ideas of traditional Chinese medicine （TCM） have led to the unclear material basis and mechanism of the medicinal effects， which is a common problem hindering the modernization of TCM in China. The introduction of computer virtual technology has provided a new perspective for TCM research. In this study， we established the research method of structure-activity omics to study the relationships between the structures and effects of different compounds in TCM based on the chemical structures of TCM components and to analyze and predict the material basis and multitarget synergistic mechanism of TCM. Furthermore， a structure-activity omics study was carried out with the anti-inflammatory and analgesic effects of Qizhi Weitong granules as an example. This study provides support for screening the pharmacodynamic components and analyzing the active ingredients of TCM and gives insights into the research on the material basis and mechanism of compound efficacy and the development of lead compounds of TCM， thus promoting the modern research and the innovative development of TCM.
