Programmed cell death and infectious diseases
- Author:
LIU Ruiqing
;
XU Hongmin
;
ZHAO Yan
;
LIU Shuye
;
SHEN Yanna
- Publication Type:Review
- Keywords:
Infectious diseases;
programmed cell death;
apoptosis;
pyroptosis;
ferroptosis;
necroptosis;
PANoptosis
- From:
China Tropical Medicine
2023;23(11):1213-
- CountryChina
- Language:Chinese
-
Abstract:
Abstract: Cell death is a fundamental biological phenomenon that is essential for the survival and development of organisms. Cell death can be either a spontaneous programmed process by the host or an accidentally triggered process. According to the different signaling pathway activated by various stimulates, programmed cell death exhibits the lytic or non-lytic morphology. For example, apoptosis, a typical non-lytic form of cell death, exhibits cell shrinkage and induces the formation of apoptotic bodies. Pyroptosis mediated by cysteine-containing aspartate-specific protease-1/11 (caspase-1/11) and necroptosis can induce inflammatory reactions and promote cell lysis to release inflammatory cytokines via triggering the pore-forming mechanism of the cell membrane, representing a typical modes of lytic cell death. In addition, the release of reactive oxygen species caused by the damaged mitochondria may further trigger ferroptosis during the pathogen infection. Programmed cell death can play an immune defensive role by eliminating infected cells and intracellular pathogens and stimulating the innate immune response through the resulting cell corpses. Here, we discuss the molecular mechanisms of five programmed cell death pathways: apoptosis, pyroptosis, ferroptosis, necroptosis and PANoptosis. We describe their roles in the innate immune defense against bacterial infections and give a brief statement of the interactions between the different programmed cell death, hoping to provide new insights for in-depth study of the pathogenic mechanisms of infectious diseases.
- Full text:20240628154007155716.Programmed cell death and infectious diseases.pdf
