Association study between mammalian sterile 20-like kinase 1 SNPs and colorectal cancer
10.19405/j.cnki.issn1000-1492.2024.03.028
- Author:
Licong Ma
1
,
2
;
Xiaoxia Yan
2
;
Fang Gao
3
;
Wenjie Dong
2
;
Yingze Li
2
;
Yanbin Jia
1
,
2
Author Information
1. Inner Mongolia Institute of Digestive Diseases,The Second Afiliated Hospital of Baotou Medical College,Baotou 014030
2. School of Basic Medicine and Forensic Medicine, Baotou Medical College,Baotou 014060
3. School of Medical Technology and Anesthesiology,Baotou Medical College,Baotou 014060
- Publication Type:Journal Article
- Keywords:
colorectal cancer;
Hippo pathway;
MST1;
single nucleotide polymorphism;
genotyping;
association study
- From:
Acta Universitatis Medicinalis Anhui
2024;59(3):547-553
- CountryChina
- Language:Chinese
-
Abstract:
Objective :To explore the association between mammalian sterile 20-like kinase 1(MST1)gene poly- morphism and haplotype and the risk of colorectal cancer,rectal cancer,and colon cancer in the Han population in Baotou area by case-control association study
Methods :A total of 390 patients with colorectal cancer diagnosed by pathology and 413 normal physical examination population were collected,and 2 ml of peripheral blood was taken for subsequent gene genotyping.Single nucleotide polymorphisms(SNPs)of MSTI gene were screened according to the genetic polymorphism data of Chinese Han population provided by the National Center for Biotechnology Information-Haplotype Mapping database.Gene genotyping was performed by Taqman method.Logistic regression was used to calculate the association between each SNP and the risk of colorectal cancer,colon cancer,and rectal cancer under codominant,dominant,overdominant,and recessive genetic models.
Results :Four SNPs of MSTI gene were screened,namely rs8000,rs2234197,rs2267853,and rs6073629.Among them,SNP rs2234197 was associated with the risk of rectal cancer.Compared with the GG+AA genotype,the AG genotype could reduce the risk of rectal cancer, OR[95%confidence interval(CI)]=0.657(0.442-0.976).SNP rs8000 was associated with the risk of colon cancer.Compared with the TT+GT genotype,theGG genotype could reduce the risk of colon cancer [OR(95%CI)=0.425(0.182, -0.992)].
Conclusion :MSTI gene SNP rs2234197 AG genotype and SNP rs8000 GG genotype may be protective factors for rectal cancer and colon cancer,respectively.
- Full text:202406280834015080哺乳动物不育系20样激酶1...多态性与结直肠癌的关联分析_马立聪.pdf
