Antimicrobial Prophylaxis Using a 2nd Generation Cephalosporin after Laparoscopic Colorectal Resection: A Randomized Trial of 1-day vs. 3-day.
10.4174/jkss.2010.78.6.385
- Author:
Han Deok KWAK
1
;
Dong Jin CHOI
;
Si Uk WOO
;
Jin KIM
;
Jun Won UM
;
Seon Hahn KIM
Author Information
1. Department of Surgery, Korea University Anam Hospital, Seoul, Korea. drkimsh@korea.ac.kr
- Publication Type:Randomized Controlled Trial ; Original Article
- Keywords:
Antimicrobial prophylaxis;
Monotherapy;
Laparoscopic colorectal surgery;
Surgical site infection;
Hospital acquired infection
- MeSH:
Academic Medical Centers;
Body Mass Index;
Colorectal Surgery;
Diabetes Mellitus;
Humans;
Korea;
Operative Time;
Prospective Studies;
Smoke;
Smoking
- From:Journal of the Korean Surgical Society
2010;78(6):385-389
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: We performed this study to compare 1-day group using a 2nd generation cephalsporin with 3-day group for evaluating hospital acquired infection. METHODS: The patients underwent laparoscopic colorectal surgery at Korea University Medical Center Anam Hospital, from August, 2007 to June, 2008. They were randomly allocated to 2 groups: 1-day or 3-day group. A 2nd generation cephalosporin was administered within 1 hour before surgery with 12-hour intervals. In cases of suspected infection, further studies were done to identify infection. RESULTS: The study included 154 patients (1-day group - 78, vs. 3-day group - 76). No differences were noted between the 2 groups in age, body mass index, smoking, diabetes mellitus, corticosteroid-use were noted. Gender (P=0.011) and mean operative time (P=0.047) between the 2 groups were different. The preventive rates of infection were 87.18% in the 1-day group compared with 82.89% in the 3-day group (P=0.456). CONCLUSION: Our prospective randomized control study concluded that there were no differences between the 1-day and 3-day group in hospital acquired infection. We could come to the conclusion that 1-day antimicrobial agent in laparoscopic colorectal surgery would be adequate in preventing infection.
