Status quo and influencing factors of drug resistance of tuberculosis in Inner Mongolia
10.19405/j.cnki.issn1000-1492.2024.03.022
- Author:
Jinqi Hao
1
,
2
;
Lan Zhang
2
;
Yanqin Yu
2
;
Mingyuan Hao
3
;
Aixin Wang
4
;
Fumin Feng
1
Author Information
1. School of Public Health , North China University of Science and Technology , Tangshan 063210
2. School of Public Health , Baotou Medical College , Inner Mongolia University of Science and Technology , Baotou 014040
3. Dept of Clinical Laboratory ,The Second Peoples Hospital of Hulunb uir , Hulunb uir 162650
4. The Third Dept of Tuberculosis , The Second Peoples Hospital of Hulunb uir , Hulunb uir 162650
- Publication Type:Journal Article
- Keywords:
mycobacterium tuberculosis;
drug resistance;
drug susceptibility testing;
mono - resistant;
multidrug - resistant;
extensively drug resistant;
influencing factors
- From:
Acta Universitatis Medicinalis Anhui
2024;59(3):515-520
- CountryChina
- Language:Chinese
-
Abstract:
Objective :To investigate the status quo of drug resistance and influencing factors of tuberculosis in Inner Mongolia , and to provide reference for accurate prevention and control of drug - resistant tuberculosis .
Methods :Random sampling was used in this study . TB patients from Tuberculosis designated hospital in Inner Mongolia were included , according to the rules and drug - resistant strains were identified and tested according to relevant norms . Composition ratio or rate was calculated for statistical description , and Logistic regression model was used to analyze the influencing factors of drug resistance in TB patients .
Results :Among 1321 patients, there were 936 males and 385 females, with an average age of (52.65 ±18 .09) years . The rates of mono - resistant , multidrug - resistant (MDR) , extensively drug - resistant (XDR) and total drug resistance were 19.00% , 11.58% , 11.66% and 42.24% , respectively . The highest resistance rates were ob served for streptomycin ( 7.27% ) , isoniazid (4.69% ) , and isoniazid + streptomycin (4.47% ) . The drug resistance spectrum presented diversity and com
plexity . Compared to females , males had a higher proportion of drug resistance , and the difference was statistically significant (P < 0.001) . The proportion of patients who were sensitive to anti - tuberculosis drugs increased with age (P < 0.05) . Among different age groups , the proportion of drug - resistant patients was higher in the 20 - 40 age group , 40 - 60 age group , and 60 and above age group compared to the 0 - 20 age group (P < 0.05) . Addi tionally , the proportion of drug - resistant patients was higher in the 20 - 40 age group and 40 - 60 age group com pared to the 60 and above age group (P < 0.05) . Moreover , the proportion of drug - resistant and multi - drug resistant patients was higher among patients undergoing retreatment compared to those undergoing initial treatment (P < 0.001) . Multivariate Logistic regression analysis showed that male gender (OR = 1.48 , 95% CI: 1.02 - 2.14) , age 20 - 40 years (OR = 2.64 , 95% CI: 1.05 - 6.60) , retreatment (OR = 2.34 , 95% CI: 1.70 - 3.22) , and outpatient follow-up (OR = 1.56 , 95% CI: 1.05 - 2.33) were independent risk factors for drug - resistant tuber culosis .
Conclusion :Inner Mongolia has a high prevalence of MDR and overall drug - resistant tuberculosis among
patients . The drug resistance profile exhibits diversity and complexity . Risk factors that contribute to drug resistance include being male , aged between 20 and 40 , undergoing retreatment , and receiving outpatient follow - up . Therefore , it is necessary to further improve clinical diagnosis and treatment , promote rational use of first - line anti - tuberculosis drugs , prioritize individualized treatment , enhance health education , improve the medical insurance system , and optimize patient management approaches in order to enhance patient compliance .
- Full text:2024062711491300097内蒙古地区结核病的耐药现状及影响因素研究_郝金奇.pdf
