Study on the functional disorder of coagulation in patients with cirrhosis
- Author:
Huy Van Tran
- Publication Type:Journal Article
- Keywords:
cirrhosis
- MeSH:
Fibrosis;
Blood Coagulation Disorders
- From:Journal of Practical Medicine
2000;383(6):25-27
- CountryViet Nam
- Language:Vietnamese
-
Abstract:
Objectives: Assess some disorder of hemostasis in the patient of cirrhosis; Estimate the correlation between these disorders and the Child-Pugh score. Methods: 30 patients of cirrhosis diagnosed upon the clinical, biological and imaging criteria, in the Department of HepatoGastroEnterology, Hue Central Hospital, from January to October 2000. Results and conclusion: The frequency of the disorder of hemostasis in the patients of cirrhosis is about 92%, the most frequent of these disorders is the prolongation of prothrombine time (83.3%). A diminution of fibrinogen concentration was found in 46.7% the cases. Significant prolongation of the time of Howell and Cephalin - Kaolin time are found respectively in 53.4% and 40%. Thrombocytopenia occurs in only 6.7%. Clinical manifestations don't reflex exactly the disorders of hemostasis, bleeding in the peritoneal cavity was found in 13.3%. There isn't any strict correlation between Child-Pugh score (CPS) and any of the hemostasis disorders. Apart from a medium correlation between CPS and prothrombin time (r=0.56, p<0.05) and concentration of fibrinogen (r=0.62, p<0.05) and minimal correlation between CPS and time of Howell (r=0.32, p<0.05) and Time of Cephalin - Kaolin (r=0.30, p>0.05)
